Pozor, data utkání jsou orientační.
| 11.07.21 | Přátelský zápas | Accrington Stanley | D | 3:0 | ||
| 17.07.21 | Přátelský zápas | Blackburn Rovers | D | 1:0 | ||
| 25.07.21 | Florida Cup | Millonarios FC | V | |||
| 28.07.21 | Florida Cup | Inter Milan/Arsenal | V | |||
| 07.08.21 | Přátelský zápas | Manchester United | V | |||
| 14.08.21 | Premier League | 1. kolo | Southampton | D | ||
| 21.08.21 | Premier League | 2. kolo | Leeds United | V | ||
| 28.08.21 | Premier League | 3. kolo | Brighton & Hove Albion | V | ||
| 11.09.21 | Premier League | 4. kolo | Burnley | D | ||
| 18.09.21 | Premier League | 5. kolo | Aston Villa | V | ||
| 25.09.21 | Premier League | 6. kolo | Norwich City | D | ||
| 02.10.21 | Premier League | 7. kolo | Manchester United | V | ||
| 16.10.21 | Premier League | 8. kolo | West Ham United | D | ||
| 23.10.21 | Premier League | 9. kolo | Watford | D | ||
| 30.10.21 | Premier League | 10. kolo | Wolverhampton Wanderers | V | ||
| 06.11.21 | Premier League | 11. kolo | Tottenham Hotspur | D | ||
| 20.11.21 | Premier League | 12. kolo | Manchester City | V | ||
| 27.11.21 | Premier League | 13. kolo | Brentford | V | ||
| 30.11.21 | Premier League | 14. kolo | Liverpool | D | ||
| 04.12.21 | Premier League | 15. kolo | Arsenal | D | ||
| 11.12.21 | Premier League | 16. kolo | Crystal Palace | V | ||
| 15.12.21 | Premier League | 17. kolo | Chelsea | V | ||
| 18.12.21 | Premier League | 18. kolo | Leicester City | D | ||
| 26.12.21 | Premier League | 20. kolo | Burnley | V | ||
| 28.12.21 | Premier League | 21. kolo | Newcastle United | D | ||
| 01.01.22 | Premier League | 22. kolo | Brighton & Hove Albion | D | ||
| 15.01.22 | Premier League | 23. kolo | Norwich City | V | ||
| 22.01.22 | Premier League | 24. kolo | Aston Villa | D | ||
| 09.02.22 | Premier League | 16. kolo | Newcastle United | V | ||
| 12.02.22 | Premier League | 25. kolo | Leeds United | D | ||
| 19.02.22 | Premier League | 26. kolo | Southampton | V | ||
| 26.02.22 | Premier League | 29. kolo | Manchester City | D | ||
| 05.03.22 | Premier League | 27. kolo | Tottenham Hotspur | V | ||
| 12.03.22 | Premier League | 28. kolo | Wolverhampton Wanderers | D | ||
| 19.03.22 | Premier League | 30. kolo | Watford | V | ||
| 02.04.22 | Premier League | 31. kolo | West Ham United | V | ||
| 09.04.22 | Premier League | 32. kolo | Manchester United | D | ||
| 16.04.22 | Premier League | 33. kolo | Crystal Palace | D | ||
| 23.04.22 | Premier League | 34. kolo | Liverpool | V | ||
| 30.04.22 | Premier League | 35. kolo | Chelsea | D | ||
| 07.05.22 | Premier League | 36. kolo | Leicester City | V | ||
| 15.05.22 | Premier League | 37. kolo | Brentford | D | ||
| 22.05.22 | Premier League | 38. kolo | Arsenal | V |
