Pozor, data utkání jsou orientační.
| 11.07.21 | Přátelský zápas | Accrington Stanley | D | 3:0 | ||
| 17.07.21 | Přátelský zápas | Blackburn Rovers | D | 1:0 | ||
| 25.07.21 | Florida Cup | Millonarios FC | N | 2:1p. | ||
| 28.07.21 | Florida Cup | Pumas UNAM | N | 1:0 | ||
| 07.08.21 | Přátelský zápas | Manchester United | V | 0:4 | ||
| 14.08.21 | Premier League | 1. kolo | Southampton | D | Preview | 3:1 |
| 21.08.21 | Premier League | 2. kolo | Leeds United | V | Preview | 2:2 |
| 24.08.21 | Ligový pohár | 2. kolo |
Huddersfield Town
|
V | Preview | 2:1 |
| 28.08.21 | Premier League | 3. kolo | Brighton & Hove Albion | V | Preview | 2:0 |
| 11.09.21 | Premier League | 4. kolo | Burnley | D | Preview | 3:1 |
| 18.09.21 | Premier League | 5. kolo | Aston Villa | V | Preview | 0:3 |
| 21.09.21 | Ligový pohár | 3. kolo | Queens Park Rangers | V | Preview | 2:3p. |
| 25.09.21 | Premier League | 6. kolo | Norwich City | D | Preview | 2:0 |
| 02.10.21 | Premier League | 7. kolo | Manchester United | V | Preview | 1:1 |
| 16.10.21 | Premier League | 8. kolo | West Ham United | D | Preview | 0:1 |
| 23.10.21 | Premier League | 9. kolo | Watford | D | Preview | 2:5 |
| 01.11.21 | Premier League | 10. kolo | Wolverhampton Wanderers | V | Preview | 1:2 |
| 07.11.21 | Premier League | 11. kolo | Tottenham Hotspur | D | Preview | 0:0 |
| 21.11.21 | Premier League | 12. kolo | Manchester City | V | Preview | 0:3 |
| 28.11.21 | Premier League | 13. kolo | Brentford | V | Preview | 0:1 |
| 01.12.21 | Premier League | 14. kolo | Liverpool | D | Preview | 1:4 |
| 06.12.21 | Premier League | 15. kolo | Arsenal | D | Preview | 2:1 |
| 12.12.21 | Premier League | 16. kolo | Crystal Palace | V | Preview | 1:3 |
| 16.12.21 | Premier League | 17. kolo | Chelsea | V | Preview | 1:1 |
| 02.01.22 | Premier League | 21. kolo | Brighton & Hove Albion | D | Preview | 2:3 |
| 08.01.22 | FA Cup | 3. kolo | Hull City | V | Preview | 3:2e |
| 15.01.22 | Premier League | 22. kolo | Norwich City | V | Preview | 1:2 |
| 22.01.22 | Premier League | 23. kolo | Aston Villa | D | Preview | 0:1 |
| 05.02.22 | FA Cup | 4. kolo | Brentford | D | Preview | 4:1 |
| 09.02.22 | Premier League | 24. kolo | Newcastle United | V | Preview | 1:3 |
| 12.02.22 | Premier League | 25. kolo | Leeds United | D | Preview | 3:0 |
| 19.02.22 | Premier League | 26. kolo | Southampton | V | Preview | 0:2 |
| 26.02.22 | Premier League | 29. kolo | Manchester City | D | Preview | 0:1 |
| 03.03.22 | FA Cup | 5. kolo | Boreham Wood | D | Preview | 2:0 |
| 07.03.22 | Premier League | 27. kolo | Tottenham Hotspur | V | Preview | 0:5 |
| 13.03.22 | Premier League | 28. kolo | Wolverhampton Wanderers | D | Preview | 0:1 |
| 17.03.22 | Premier League | 20. kolo | Newcastle United | D | Preview | 1:0 |
| 19.03.22 | FA Cup | Čtvrtfinále | Crystal Palace | V | Preview | 0:4 |
| 03.04.22 | Premier League | 31. kolo | West Ham United | V | Preview | 1:2 |
| 06.04.22 | Premier League | 19. kolo | Burnley | V | Preview | 2:3 |
| 09.04.22 | Premier League | 32. kolo | Manchester United | D | Preview | 1:0 |
| 20.04.22 | Premier League | 18. kolo | Leicester City | D | Preview | 1:1 |
| 24.04.22 | Premier League | 34. kolo | Liverpool | V | Preview | 0:2 |
| 01.05.22 | Premier League | 35. kolo | Chelsea | D | Preview | 1:0 |
| 07.05.22 | Premier League | 36. kolo | Leicester City | V | Preview | 2:1 |
| 11.05.22 | Premier League | 30. kolo | Watford | V | Preview | 0:0 |
| 15.05.22 | Premier League | 37. kolo | Brentford | D | Preview | 2:3 |
| 19.05.22 | Premier League | 33. kolo | Crystal Palace | D | Preview | 3:2 |
| 22.05.22 | Premier League | 38. kolo | Arsenal | V |
